الفهرس 
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Abstract
Atherosclerosis has been increasingly recognized as a complex and multifactorial inflammatory disease rather being a simply process of lipid accumulation of the wall of the medium sized and large arteries. Inflammation plays a key role in the initiation, progression and complications of atherosclerosis by mediating every stage of the atheroma development.(Selcuk et al., 2012)
This is study aimed to evaluate the value of PLR as a predictor of coronary artery disease severity.
The present study is a prospective study which was conducted in Menoufia university hospital. Data was collected from 130 patients undergoing elective coronary angiography. Patients were divided according to their gensini score into three groups:
• group one: patients with normal coronary angiography(n=26).
• group two: patients with mild atherosclerotic coronary artery disease (n=46).
• group three: patients with severe atherosclerotic coronary artery disease (n=58).
They were assessed for baseline characteristics, laboratory data.
According to the current study:
• Patients in the severe atherosclerosis group were significantly older compared to those in the mild atherosclerosis group and controls(p=0.03).
• The severe atherosclerosis group and mild atherosclerosis group had significantly lower HDL levels compared to controls (p<0.001 for both).
• The mean serum creatinine level of the severe atherosclerosis group was found to be higher than control and mild atherosclerosis groups (p<0.001).
• WBC counts were significantly higher in the severe atherosclerosis group than in the other two groups (p<0.001).
• The severe atherosclerosis group had significantly higher platelet counts compared to both the mild atherosclerosis group and control group (p=0.006).
• PLR was higher in severe atherosclerosis group than the other two groups (p=0.001). PLR was significantly higher in the severe atherosclerosis group compared to the mild atherosclerosis (p=0.01) and control groups (p=0.004).
• There was significantly higher percentage of patients with high PLR in the severe atherosclerosis group than in the other groups (p<0.001).
• PLR was found to be correlated with Gensini scores (r=0.87, p<0.001).
• Using a cut-off level of 126.5 , PLR predicted severe atherosclerosis with a sensitivity of 86 % and specificity of 84%