الفهرس 
Effect of Progesterone on Prevention of Preterm LaborOnly 14 pages are availabe for public view
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Abstract
Placenta previa is associated with life-threatening hemorrhages that can occur antepartum, intrapartum and postpartum. Cesarean section, administration of uterotonic agents, surgical hemostatic sutures and blood transfusions are classically performed to manage this situation. Despite this, some cases cannot be controlled properly and emergent peripartum hysterectomy remains a valuable and lifesaving option. Not surprisingly, the need for hysterectomy is significantly enhanced in women with placenta previa with a relative risk of 30–40 . It is, however, a demanding surgical procedure that is associated to a high rate of complications and to the risk of maternal death. There is thus the need to clearly identify the risk factors for this condition, so that women at high risk may be referred and counseled properly.
Symptomatic placenta previa are being treated with tocolytic agents. The progesterone is necessary for the preservation of pregnancy and aids in the extension of pregnancy. The progesterone is also a key metabolic intermediate in the making of other endogenous steroids such as the sex hormones and the corticosteroids. They show a vital part in brain function as a neurosteroid. Reduction of the rate of long-term morbidity requires delayed delivery which facilitates the maturity of vital organs. Though the thorough mechanism of action is not known but proposed mechanisms were: It acts principally through creating uterine inertness and upholds cervical length. It has immunosuppressive activity and stops consequence of oxytocin on myometrium. It is a powerful inhibitor of gap junctions between myometrial cells.