الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus infection affects more than 170 million people worldwide; Patients with HCV may develop chronic infection that may result in liver cirrhosis, hepatic failure or HCC.
A number of viruses and host genetic factors may affect the risk for development of HCV infection and HCC, one of host genetic parameter is genetic polymorphism
The detection of genetic polymorphism within TLR7 may be associated the development of HCV infection and HCC on top of chronic HCV.
This study aimed to determine the association between TLR7 (rs179008 gene) polymorphism and ( chronic hepatitis C infection with and without Hepatocellular Carcinoma.)
Twenty nine patients with chronic hepatitis C virus infection not associated with hepatocellular carcinoma, 17 males and 12 females. Thirty patients with chronic hepatitis C virus infection associated with hepatocellular carcinoma , 16 males and 14 females. Twenty one healthy persons as a control
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group, 11females and 10 males. included in this study.
The subjects results analyesd according to TLR7 SNP into male with either (A or T) alleles and females either with (AA , AT or TT) alleles that is because TLR7 gene located in X chromosome.
All subjects included in the study were investigated for TLR7 gene polymorphism by Real time PCR technique.
The frequency of (A) genotype was (82.4%) of HCV male patients and (90%) of control group and The frequency of (T) genotype was (17.6%) of HCV male patients and (10%) of control group. The difference between the two groups for genotypes were statistically not significant.
The frequency of (A) genotype was (93.8%) of HCC male patients and (90%) of control group. The frequency of (T) genotypes was (6.3%) of HCC male patients and (10%) of control group. The difference between the two groups for genotypes were statistically not significant.
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The frequency of (AA) genotype was (58.3%) of HCV female patients and (90.9%) of control group and the frequency of (AT) genotype was (41.7%) of HCV female patients and (9.1%) of control group. None of the both groups was (TT) genotype. The difference between the two groups for genotypes were statistically not significant.
The frequency of (AT) genotype was (50%) of HCC female patients and only (9.1%) of control group and the frequency of (AA) genotype was (42.9%) of HCC female patients and (90.9%) of control group. Only (7.1%) of female HCC cases and none of the control group was (TT) genotype. The (AT) genotype was significantly higher in female HCC group.
The frequency of (A) genotype was (82.4%) of HCV male patients and (93.8%) of HCC male patients and (17.6%) of HCV male patients and (6.3%) of HCC male patients was (T) genotype. The difference between the two groups for genotypes were statistically not significant.
The frequency of (AA) genotype was (58.3%) of HCV female patients and (42.9%) of HCC female patients and (41.7%) of HCV female patients and (50.0%) of HCC female patients were (AT) genotype and (7.1%)
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of HCC female patients and (0%) of HCV female patients were (TT) genotype .The difference between the two groups for all genotypes were statistically not significant.
No statistically significant difference of serum AFP among the different TLR7 genotypes was detected