الفهرس | Only 14 pages are availabe for public view |
Abstract Lung cancer is the most dominant type of cancer causes death in both man and women whole around the world, the survival rate of lung cancer is poor with a global 5-year survival rate lower than 20 %. The outcome becomes more favorable when the cancer has detected early, thus allowing a curative radiation therapy; so an urgent need is required for enhance target volume for accurate radiation therapy. Positron emission tomography-computed tomography (PET-CT) is becoming more and more important in various aspects of oncology. Until recently, it was used mainly as part of diagnostic procedures and for evaluation of treatment results. With development of personalized radiotherapy, volumetric and radiobiological characteristics of individual tumor have become integrated in the multistep radiotherapy (RT) planning process. Standard anatomical imaging used to select and delineate RT target volumes can be enriched by the information on tumor biology gained by PET-CT. In this work, 11 patients underwanted PET-CT study were prepared for selection to radiation therapy treatment. The selected patients were in “early stage hasn’t metastases”. These patients were split into two groups; group 1 in which the planning target volume-computed tomography (PTVCT) delineated was larger than planning target volume - positron emission tomography (PTVPET).This group contains seven patients. In-group 2 the planning target volume of computed tomography (PTVCT) was smaller than that of positron emission tomography (PTVPET) and it contains4 patients. Two plans were created for each patient; the first plan depends on only computed tomography images as PTVCT and the second plan depends on PET-CT fused images and PTVPET as target volume. Physical (Dose Distribution, Dose Volume Histograms (DVHs), Homogeneity Index (HI), Modified Homogeneity Index (MHI), Target XIII Coverage Index (TCI), etc) and radiobiological evaluation (tumor control probability and normal tissue complication probability) were created for each plan and compared for each patients. Our results showed a significant impact of using PET-CT in radiation treatment of lung cancer |