الفهرس | Only 14 pages are availabe for public view |
Abstract The repair of extensive bone defects, caused by either traumas or pathologies, constituted a great problem for both Medicine and Dentistry. Despite the great potential of repair by bone tissue, in some situations, according to the proportion of defects, the regeneration cannot be completed because the defect can be invaded by the surrounding conjunctive tissue which has a proliferation and cellular migration speed faster than those of bone tissue. Thus, the use of bone grafting can collaborate with the repair process. The presence of osteoblasts is an important requisite in the effectiveness and success of the bone repairing. This osteoblastic differentiation is commonly evaluated through different protein markers, among them bone morphogenetic protein-2 (BMP-2). In the recent past, a multitude of drugs or components with antiresorptive, anabolic or even combined activities have been identified and their effect is still under investigation. One such new experimental drug is simvastatin – a statin which has shown promising results in fracture healing in rodents. Studies have shown that statins may exert bone anabolic effects through increasing the expression of BMP-2 and thus, may enhance fracture healing (1). In view of the recent developments, the present study was undertaken to assess the effect of simvastatin on the expression of BMP-2 and its influence on bone repair. |