الفهرس 
History of Thyroid HormoneOnly 14 pages are availabe for public view
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Abstract
Thyroid hormones have marked effects on the growth, development and metabolic function of virtually all organs and tissues. It is well known that changes in the thyroid state are associated with marked alterations in cardiac growth and different brain functions.Although a pivotal role of thyroid hormones in the developing mammalian brain has been long established and extensively documented,the adult central nervous system(CNS)was generally assumed to be a thyroid hormone-insensitive organ until the 1980. A number of findings in more recent literature have casted doubt upon this assumption and have gradually led to the general acceptance of the notion that the adult brain is a highly TH-sensitive organ.This notion is in line with the well-known psychomotor and cognitive dysfunction often observed in adult-onset thyroid disorders .THs and several TH derivatives are widely distributed in the CNS. For instance, both T4 and T3 concentrations have been reported in the pmol/g range in rat hypothalamus.