الفهرس 
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Abstract
Childhood is a critical period for bone mineralization, during these periods children are liable for osteopenia and bone fractures. Epilepsy is a disease of the central nervous system which requires long-term and sometimes lifelong therapy with antiepileptic drugs (AEDs). Approximately 1.8% loss of bone mineral density (BMD) was reported in patients on anti-epileptic drugs, yielding 2.5 fold increase of bone loss when compared to healthy population.
Dual X-ray absorptiometry (DXA) is the preferred technique for measuring bone mineral density (BMD) as it detect bone loss as early as possible( 2-5% bone loss). Unfortunately there is no single diagnostic laboratory test which can reliably diagnose early bone loss.
This study was conducted in order to evaluate bone mineral density (BMD) in children with idiopathic epilepsy under anti-epileptic drugs and to determine clinically and laboratory factors associated with diminished bone mineral density in those patients.
Our study was conducted on 60 children with idiopathic epilepsy. They were 38 males and 22 females aged from 5 -12 years on antiepileptic drugs at outpatient Neurological clinic of Minia University Hospital during period from April 2016 to August 2016. In addition 60 healthy children were age and sex matched as control group.
All studied children were subjected to careful history taking, clinical examination, and laboratory investigations: serum calcium, phosphorus and alkaline phosphatase and radiological investigation: DXA scan.
The results could be summarized as follow:
• Our study reveals higher significant difference regarding ALP level between patients and control groups.
• On the other hand, there was no difference as regarding serum Ca and P between patients and control groups.
• Our study revealed that abnormal bone mineral density (LBMD) Z- score occur with children on antiepileptic drugs at least 1 year which was very significant statistically.
• Our study revealed that there were higher statistical difference as regarding LBMD which occur more with (old antiepileptic drugs) as Valproic and carbamazepine than new drugs as Levetiracetam.
• Our study reveals higher significant difference regarding duration of drug administration where LBMD occur more with long duration of AEDS administration.
• Our study revealed that poly therapy affect bone mineral density than monotherapy in epileptic children which was very significant statistically.