الفهرس 
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Abstract
Liver is a vital organ which is responsible for many biochemical reactions, supports almost every other organ in the body. Owing to its strategic position and multiple functions, many diseases also affect the liver. Liver cirrhosis is considered one of the most common diseases that affect liver. There are several causes for induction of liver cirrhosis one of them is administration of some minerals like, carbon tetrachloride. Carbon tetrachloride is one of the most commonly used hepatotoxins in the experimenttal study of liver diseases. The hepatotoxic effects of CCl4 are largely due to its active metabolite, trichloromethyl radical. This study is carried out to investigate the beneficial effect of selenium as effective antioxidant to reduce the hepatotoxic effects induced by carbon tetrachloride. Rats were divided into 4 groups: group I, received control diet, group II received control diet plus sodium selenite in water, group III received control diet in addition to intragastic administration of carbon tetrachloride, group IV received carbon tetrachloride plus sodium selenite. Blood and tissue sample were collected after 6 weeks for measurement of liver function tests: ALT, AST activities, albumin and total protein, oxidative stress markers: tissue hydrogen peroxide (H2O2), serum lipid peroxide; malondialdhyde (MDA) and nitric oxide (NO); whole blood and tissue antioxidant: glutathione reductase (GRD) activity, superoxide dismutase (SOD) activity and reduced glutathione (GSH) also collagen, tumor necrosis factor alpha (TNFα) genes expression, and histopathological examination of liver.