الفهرس | Only 14 pages are availabe for public view |
Abstract Migraine is a recurrent neurovascular disorder which lowers the quality of life. Severe head pain, in addition to the symptoms of nausea and vomiting, is the most bothersome complaint of these patients. Usually, light and sound can have an effect on the severity and frequency of these symptoms. Middle-aged women are more susceptible to migraine occurrence than men. It is divided into migraine with aura or migraine without aura (Sadeghi et al., 2016). Molecular genetic studies of migraine have investigated many polymorphisms possibly associated with migraine. The most common examined gene is MTHFR gene polymorphism (Kowalska et al., 2016). MTHFR enzyme plays a key role in homocysteine metabolism and DNA methylation which is encoded by MTHFR gene. MTHFR gene polymorphism C677T reduces the enzymatic activity resulting in increased homocysteine concentrations, and reduced methylation capacity (Tsang et al., 2015). This study was conducted on 45 subjects who were divided into two groups.GroupI (patients group) which included thirty (30) adult patients with migraine recruited from headache clinic in Ain Shams University hospitals, they were diagnosed with migraine according to ICHD diagnostic criteria 3rd edition beta version (2013) and group II (control group) which included 15 age and sex matched apparently healthy subject. The present study aimed to assess the association between MTHFR gene polymorphism and different types of migraine. The results of the present study revealed that there was a significant difference between MTHFR gene polymorphism (C677T) and migraine (P<0.05). When comparative statistics was done between genotypes of MTHFR gene polymorphism and different clinical data of migraine it showed highly significant difference between aura and MTHFR gene polymorphism. Homozygous TT genotype was higher in patients suffer from aura. Regarding the associated symptoms of migraine, the study showed significant difference between MTHFR gene polymorphism and photophobia and phonophobia. Heterozygous genotypes (CT) was higher in patients suffer from photophobia and phonophobia No significant difference between other clinical data of migraine and MTHFR gene polymorphism. In conclusion, this study had demonstrated that there was a significant difference between MTHFR gene polymorphism (C677T) and migraine .Patients with heterozygous type (CT) more susceptible to aura while patients with homozygous type (TT) more susceptible to attack of migraine associated with photophobia or phonophobia or both. |