الفهرس 
CHEMISTRY AND APPLICATIONS OF ISOCYANATE AND ISOTHIOCYANATE DERIVATIVESOnly 14 pages are availabe for public view
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Abstract
The original work presented in this thesis aims at studying the reactions of different nucleophilic active phosphacumulenes and stabilized phosphonium ylides with active centers in certain isothiocyanate and isocyanate derivatives. The reaction products depend on the nature of the reagent, substrate and the conditions of the reaction used. New heterocyclic 4-membered or 6-membered sulphur and nitrogen compounds such as phosphoranylidene, thietane, thiazinane, azetidine were obtained. On the other hand, the stable phosphonium ylides with the iso(thio)cyanate afforded phosphoranylidene thiocarbamoyl derivatives. Possible reaction mechanisms are considered and the structural assignments are based on compatible analytical and spectroscopic data.
The in vitro cytotoxic activity results of the synthesized compounds against human cancer cell lines (HepG2 and breast MCF-7) indicated that all compounds showed growth inhibitor activity against liver HepG2, and breast MCF-7 cancer cell.
Key Words:
isothiocyanate, isocyanate, phosphonium ylides, phosphoran-ylidene, thietane, thiazinane, azetidine, thiocarbamoyls, cytotoxic activity.