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Abstract Summary Introduction: Thalassemia is an Inherited hemoglobin-related disorders. Life expectancy in patients with thalassemia major is still limited by development of congestive heart failure due to a cardiomyopathy associated with iron overload .The early detection and treatment of heart failure due to any reason in patients with thalassemia major improve the prognosis and increase the life expectancy. Echocardiography is a useful and non invasive diagnostic tool for diagnosis of heart disorders and helps with early detection of heart failure before the development of symptoms. 2D strain analysis technique is a new method for assessment of myocardial function. It offers many advantages as it is less time-consuming, angle independent, can assess strain in 3 dimensions. Magnetic Resonance Imaging: (MRI) has emerged as a powerful and reliable tool to non invasively study the cardiovascular system in clinical practice. The technique can also provide critical insights into cardiac and vascular morphology, function, and physiology. |