الفهرس | Only 14 pages are availabe for public view |
Abstract Alendronate is a nitrogen containing bisphosphonate widely used in the treatment of post-menopausal osteoporosis, corticosteroid-induced osteoporosis, Paget’s disease as well as multiple myeloma. Its long term administration could produce a wide variety of adverse effects among many organs including the submandibular salivary glands. Propolis is a natural resinous substance collected by honeybees from buds and exudates of different plants. It has broad spectrum pharmacological effects especially antioxidant and anti-inflammatory effects. So it is widely used in the treatment of various conditions such as inflammations, microbial infections, wounds, burns, sore throat, ulcers as well as diabetes, cardiac diseases and even cancer. This study was conducted to evaluate the effect of alendronate on the histological structure of the submandibular salivary gland of adult male albino rat and the possible protective effect of propolis using light microscope, α-SMA immunohistochemistry stain and electron microscopy. The present study was carried out on 40 adult male albino rats weighing from 120 to 180 grams and were housed in suitable clean properly ventilated cages under similar environmental conditions. They were divided into two main groups: (I) Control group: It included 10 rats that were subdivided into two further subgroups (5 rats each). Subgroup C1: included 5 rats kept without treatment. |