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Abstract This study was conduced to investigate the effect of rose petals (Rosa damascena) powder (RPP) on blood lipids and glucose in experimental rats. Fifty-Four adult male albino rats weighing150±10g, were used, and divided into three main groups ,First group (5 rats) fed on basal diet as control (-),Second group was induced diabetes by aloxan (150 mg/kg) , third group was induced hyperlipidemia by fed rats on diet containing high lipids( basal diet + 20 % animal fat sheep’s tail) for three consecutive weeks . Diabetic and hyperlipidmic rats groups divided into four sub groups, 5 rats per each, two of them were diabetic and hyperlipidimic control positive. While the other groups fed a basal diet after replacing 1, 2.5 and 5% RPP and feeding continued for 30 days. After the treatment, body weight, feed intake (FI),(FER) were measured and blood samples serum glucose, triglyceride, total cholesterol ,LDL-C, AST, ALT and ALP levels were determinid, while HDL-C and VLDL-C were calculated and Histopathological structure of liver has been evaluated. The obtained results revealed that feeding on RPP caused significant (P ≤ 0.05) improvements in weight gain, FI, FER , HDLc, , but with significant (P ≤ 0.05) decreases in the rest of the parameters as compared with control (+ve) group. Histopathological investigations confirmed the biochemical changes in rats serum . It could be concluded that rosa petals powder was effective in protecting against diabetic and hyperlipidimic rats not only decreased the level of serum glucose but also has beneficial effect on serum lipids and liver functions .Therefore, data recommended the RPP tested plant by a moderate amount (5%) to be included in our daily drinks and diets. |