الفهرس 
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Abstract
Background: DW-MRI is a functional, non-invasive imaging technique which generates tissue contrast from differences in mobility of water molecules that occurs during an MR pulse sequence. Information regarding the integrity of cellular membranes and tissue cellularity can be obtained, so that DW-MRI can now be included in routine patient assessment. Aim of the Work: The aim of this study is to evaluate the role of diffusion weighted magnetic resonance imaging (DW-MRI) in the diagnosis of cervical carcinoma, with pathological diagnosis was taken as the reference. Patients and Methods: This is a retrospective study that included 20 patients in whom cervical cancer had been suspected clinically or by Trans vaginal U/S and the control group consisted of 20 patients in whom cervical cancer had been not suspected and MRI was performed because of other Pelvic diseases. The study was conducted in El-Demerdash hospital. The patients were referred from the gynecology department to the radiology department (Women’s imaging unit) for further MRI assessment with DWIs. Results: Lesions in all cases show restricted diffusion, however on ADC map only one case show high signal proved to be chronic cervicitis on histopathology. Also, the mean ADC values for malignant lesions were (0.82 x10-3 mm2/sec), while the mean ADC value in the control group is (1.58x10–3 mm2/sec). Therefore ADC value of (1.04 x10-3 mm2/sec) is a cut off between normal cervical tissue & malignant cervical lesion by sensitivity 95% and specificity 95 %. DWIs had elicited the same accuracy to DCE sequences (95%) when added to the non-contrast MRI in the estimation of cancer cervix. Conclusion: Our results proved that (DW–MRI) was significantly beneficial in terms of diagnostic performance that increases the radiologist’s confidence in image interpretation. So it implies a non-invasive technique which can be used especially if contrast intake is avoided as in pregnancy. Thus, we suggest that DWI should be included in the routine pelvic MRI protocol. The ADC value in case of cervical carcinoma was significantly lower than in the normal cervical tissue. The ADC threshold of (1.04 x10-3 mm2/sec) is a cut off value was detected when differentiating between cancer-affected and non-affected cervical tissues