الفهرس 
ObesityOnly 14 pages are availabe for public view
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Abstract
The present work was conducted to study the chemical
composition of Helianthus Tuberosus and the effect of four
levels from (Helianthus Tuberosus) on some nutritional and
biological parameters in rats suffering from obesity and chronic
liver diseases. Normal male’s albino rats (35) of Sprague
Dawley Strain weighted 150 ± 10 g. used in this study. The rats
divided into two main groups. The first main group (6 rats) fed
on basal diet (as a control negative group). The second main
group was fed 6 week on high fat diet HFD to induce obesity in
rats, then the rats in the second main group were treated with
CCl4 in paraffin oil (50% v/v 2ml/kg) twice a week
subcutaneous injection (for two weeks) to induce chronic
damage in the liver. Then the rats in this group were divided
into 5 subgroups, one of them fed on high fat diet ―control +ve
group‖ and the other subgroups fed on high fat diets containing
different levels of Helianthus Tuberosus (2.5%, 5%, 7.5% and
10%).
The obtained results can be summarized as follows:
Chemical composition of Helianthus Tuberosus:
The amounts of moisture, protein, ash, crud fiber, oil
and Soluble carbohydrates were 10.500, 8.841, 6.22, 3.250,
0.61 and 70.579%, respectively. On the other hand the
amounts of total sugars and inulin were 29.250 and 20.490%,
respectively Biological Evaluation:
Effect of Some Levels of Helianthus tuberosus as Source of
Inulin on Nutritional Parameters of Rats Suffering from
Obesity and chronic Liver Diseases.
The mean value of fed intake in healthy group ―control
negative group‖ showed non-significant changes, as compared
to obese group which suffer from chronic liver disease
―control positive group‖ and the other treated groups.
Non-significant differences in initial weight in all groups. On
the other hand, the final weight of the positive control group
increased significantly, as compared the final weight of the
negative control group. The final weight of all treated groups
decreased significantly, as compared to the positive control
group. The highest decrease in the final weight recorded for
the groups treated with (5%, 7.5% and 10%) Helianthus
tuberosus.
The mean value of body weight gain % of the positive
control group ―obese rats suffering from chronic liver
diseases‖ increased significantly, as compared to the negative
control group ―healthy rats). All treated groups showed
significant decrease in BWG%, as compared to the positive
control group. The highest decrease in BWG% recorded for
the groups treated with (7.5% and 10%) Helianthus tuberosus.
Effect of Some Levels of Helianthus tuberosus as Source of
Inulin on Organs Weight/Body Weight% of Rats Suffering
from Obesity and chronic Liver Diseases. The mean value of liver, kidney, heart and spleen
weight/body weight% in obese group which suffering from
chronic liver diseases ―control positive group‖ showed
significant increase, as compared to healthy rats ―control
negative group‖.
Treating obese rats which suffer from chronic liver diseases
with (2.5%, 5%, 7.5% and 10%) Helianthus tuberosus
improved the mean value of liver, kidney, heart and spleen
weight/body weight%.
The highest improvement of these organs recorded for the
groups treated with the high levels of Helianthus tuberosus.
Effect of Some Levels of Helianthus Tuberosus as Source of
Inulin on Serum Glucose and Leptin hormone of Rats
Suffering from Obesity and chronic Liver Diseases.
The mean value of serum glucose and leptin hormone in
obese group which suffering from chronic liver diseases
―control positive group‖ increased significantly, as compared
to healthy rats ―control negative group‖.
Treating obese rats which suffer from chronic liver diseases
with (2.5%, 5%, 7.5% and 10%) Helianthus tuberosus
decreased the mean value of serum glucose and leptin
hormone, as compared to the positive control group.
Serum glucose and leptin hormone decreased gradually with
increasing the levels of Helianthus tuberosus.The highest decrease of these parameters recorded for the
group treated with the high levels of Helianthus tuberosus
(10%).
Effect of Some Levels of Helianthus Tuberosus as Source of
Inulin on Lipid Profile of Rats Suffering from Obesity and
Chronic Liver Diseases.
Feeding rats on high fat diet increased the mean value of
serum cholesterol, triglycerides, low and very low density
lipoprotein-cholesterol (LDL-c and VLDL-c), while high
density lipoprotein-cholesterol (HDL-c) decreased, as
compared to the rats fed on basal diets.
Treating obese rats with high fat high fat diet containing
deferent levels of Helianthus tuberosus (2.5%, 5%, 7.5% and
10%) led to significant decrease in serum cholesterol,
triglycerides, LDL-c and VLDL-c, while HDL-c increased, as
compared to non-treated group (obese group).
The highest improvement of serum cholesterol, triglycerides,
LDL-c, HDL-c and VLDL-c recorded for the groups treated
with the highest levels of Helianthus tuberosus (7.5% and
10%).
Effect of Some Levels of Helianthus Tuberosus as Source of
Inulin on Liver Enzymes of Rats Suffering from Obesity and
Chronic Liver Diseases.
Feeding rats which were suffer from obesity and chronic
liver diseases on high fat diet increased the mean value of
serum AST, ALT and ALP, as compared to the rats fed on
basal diet.Treating obese rats with high fat high fat diet containing
deferent levels of Helianthus tuberosus (2.5%, 5%, 7.5% and
10%) led to significant decrease in serum AST, ALT and ALP
enzymes, as compared to non-treated group (obese group).
The highest improvement of serum AST, ALT and ALP
recorded for the group treated with 7.5% Helianthus tuberosus
, followed by the group treated with 10% Helianthus
tuberosus, respectively.
Effect of Some Levels of Helianthus Tuberosus as Source of
Inulin on Kidney Functions of Rats Suffering from Obesity
and chronic Liver Diseases.
Injected rats which were suffer from obesity with ccl4 to
induce chronic liver diseases increased the mean value of
serum uric acid, urea nitrogen and creatinine, as compared to
the healthy rats fed on basal diet.
Treating obese rats which were suffering from chronic liver
diseases with high fat high fat diet containing deferent levels
of Helianthus tuberosus (2.5%, 5%, 7.5% and 10%) led to
significant decrease in serum uric acid, urea nitrogen and
creatinine, as compared to non-treated group (obese group).
The highest improvement of serum uric acid, urea nitrogen
and creatinine recorded for the group treated with 7.5%
Helianthus tuberosus , followed by the group treated with 10%
Helianthus tuberosus, respectively.