الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Introduction: Breast cancers are the most common cancers affecting females worldwide; the incidence of breast cancers new cases was more than 1,700,000 cases per year. Moreover, breast cancers are responsible for about 700,000 deaths worldwide every year, (Ferlay, et al., 2013).
Aim of work: this study aimed to study the relationship between type II diabetes mellitus and breast cancers among Egyptian females.
Patient and methods: Our study included 53 Egyptian females with breast cancers that prepared for surgical mastectomy either in Minia university hospital or Minia oncology center. Participants of this study were arranged into two groups according to D.M status: group (I): Type II diabetic Egyptian females with breast cancer & group (II): Non-diabetic Egyptian females with breast cancer. Multiple breast tissue biopsies obtained from malignant breast tissues and adjacent normal tissues obtained from free margins then fixed and stained with IHC stain to assess: Breast Tissue Estrogen Receptors (ER), Progesterone Receptors (PR), Chemerin expression and IGF-1 receptors expression
Results: The current study disclosed that Egyptian diabetic females with breast cancers are presented with higher breast cancers TNM scoring; larger tumor size (p value = 0.03), higher incidence of L.N metastasis (p value = 0.02), and higher incidence of distant metastasis (p value = 0.01) when compared with their non-diabetic counterparts.
In addition, this study showed that Egyptian diabetic females with breast cancers are more frequently presented with more aggressive breast cancers phenotypes with significantly higher tumor grades (p value = 0.001), higher incidence of ER negative (p value = 0.01), and PR negative breast cancers (p value = 0.03) when compared with their non-diabetic counterparts. These data reflect the poor prognostic effect of type II diabetes mellitus on outcomes of breast cancers among Egyptian females.
Conclusions: IGF-1R Over-expression was an independent risk factor for development and progression of breast cancers among Egyptian females.