الفهرس 
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Abstract
This study was done on 30 selected acute viral hepatitis patients, B (14 patients) and C (16
patients) (26 males & 4 females) their ages ranged between 18 - 67 years and 38 selected chronic
viral hepatitis patients, B (18 patients) and C (20 patients) (29 males and 9 females) their ages
ranged between 24 - 64 years. In addition, 12 adult persons (9 males and 3 females) their ages
ranged between 33 -67 years as control group.
They were subjected to the following studies:
+ Careful history and thorough clinical examination.
+ Investigations to prove the presence of the disease:
1) Complete liver profile.
2) Abdominal ultrasound.
3) Histopathological examination of liver biopsies in
chronic cases.
4} Viral markers for acute and chronic hepatotropic vrruses.
+ Investigations to exclude other associated diseases and
other etiologies:
1) Complete blood picture.
2) Stool and urine analysis.
3) Sigmoidoscopy and rectal snips.
4) iliAT for bilharziasis.5) ESR and collagen markers as R.F, ANA, AMA, ASMA and LKM-1
+ Investigations to search for any complications such as:
I. Upper endoscopy.·
II. Imaging Technique.
III. Tumour markers such as a-fetop:mtein.
+ Serum concentration of siCAM-1 by ELIZA technique.
+ The statistical analysis of results of the study was made.
The mean serum levels of siCAM-1 were higher in patients with acute hepatitis C (1521 ng/ml) and B
(1566 ng/ml) than· in chronic hepatitis C (846 ng/ml) and B (874 ng/ml) and all were higher than
its level in the control group (343 ng/ml). These results could point to the importance role of
siCAM-1 in liver cell damage in hepatitis but not related to the cause of this damage.
We found significant correlation between siCAM-1 levels and the degree of hepatic damage at
biopsy. These observations suggest that measurement of siCAM-1 levels in chronic hepatitis C and B
patients may be useful for monitoring liver inflammation.
The results of liver function tests in different groups only
.·reflect hepatocellular necrosis but not the degree of hepatic damage in comparison with
siCAM-1 in each group.