الفهرس 
Diabetes Mellitus
Etiology of type II diabetes:Only 14 pages are availabe for public view
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Abstract
Type 2 diabetes mellitus is a chronic progressive disease and the most common form of diabetes mellitus,it results from an imbalance between insulin sensitivity and insulin secretion.Glucose production fails to be regulated adequately by insulin, leading to hepatic glucose overproduction and diminished glucose uptake by muscle tissue.Obesity is the most frequently encountered metabolic disease worldwide.Moreover, its incidence and prevalence are rising rapidly. It is generally considered to be a strong risk for the later development of Type 2 diabetes mellitus as it can cause increased insulin resistance.The insulin receptor is usually expressed at low levels in all cell types except in insulin target tissues where insulin receptor is expressed at a very high level. The identification of genetic defects in human insulin receptor gene that are associated with extreme insulin resistance and glucose intolerance has provided insight into the possible role of the human insulin receptor gene in the development of non-insulin dependent diabetes mellitus The aim of this study was to identify any mutations in exon 13 of the insulin receptor gene by DNA sequencing which may cause insulin resistance in a group of Egyptian patients with type II DM and compare the obtained results to that reported in other populations.