الفهرس 
Genetic Basis Of CancerOnly 14 pages are availabe for public view
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Abstract
reast cancer is a major cause of mortality in ”11’-,l females all over the world. The genetic
factor of the disease has been reported to have an
important role in the development of the disease. The principle genetic lesions observed include
gene amplification, deletion, point mutation, loss of heterozygosity (LOH), and overall
aneuploidy. Genes have been cloned (p53 and BRCAl) and another localized (BRCA2) whose function as
tumour suppressor genes are compromised when inherited as mutant alleles. A progressive cascade of
genetic changes occurs in the course of development of breast cancer. Successive generations of
tumour cells overgrow and dominate the tissue, eventually giving rise to clonal or nearly clonal
metastatic disease. Genetics of inherited breast cancer also is an important subject to study.
Finally, the most recent methods and strategies of biologic and gene therapy of breast cancer,
antibodies and vaccines were also summarized in this essay.