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Abstract Attention deficit hyperactivity disorder (ADHD) is considered one of the most common neurobehavioral disorders of childhood. In recent years, the impacts of various hormones on ADHD have been studied. However, testosterone has received much less attention. The aim of this study was therefore to investigate serum total testosterone level in children with ADHD. METHODS: This is a case control study of 70 ADHD patients were recruited from Child and adolescent psychiatry clinic in the children hospital, Ain shams university and 30 healthy controls were included in the study. The mean age of both groups was 7.82 + 1.4 and 7.52 + 1.4 years old respectively. Serum total testosterone was measured by Electrochemiluminescence immunoassay. RESULTS: Serum total testosterone was found to be significantly higher in children with ADHD compared to healthy controls (P <0.01). CONCLUSION: This study has evidenced a significant high level of serum total testosterone in children with ADHD. There is an association between higher serum total testosterone concentration and ADHD in childhood. Therefore there is a need for regular monitoring of serum total testosterone levels and treatment of patients with high testosterone level. |