الفهرس 
Salivary glandsOnly 14 pages are availabe for public view
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Abstract
Abstract Salivary glands are exocrine glands whose secretions flow into the oral cavity. However, xerostomia is a decrease in salivary flowr (hyposalivation), leading to a complaint of dry mouth, it is common in older people. Pilocarpine considered a treatment exists clinically which aim to increase the salivary secretion and thereby the oral health and comfort. Also, green tea was believed to be as a potent source of beneficial antioxidants which proved to be a good defense mechanism against free radical effects. Thus, the aim of the present study would be directed to compare the protective effect of pilocarpine versus green tea on submandibular salivary (SMG) gland of Albino rats that would be treated by methotrexate. Sixty male albino rats were assigned into two groups; control and experimental group. The experimental group was divided to methotrexate (MTX) sub group, pilocarpine sub group and green tea sub group. We used histological examination, transmission electron microscope and immune reactivity examination to assist our
result. The histological result showed decrease degeneration of SMG acini and cytoplasmic vacuolation in green tea sub group in comparison to pilocarpine and MTX sub group. However, in the same direction the immunohistochemistry showed increase in nuclei regeneration in green tea sub group in relation to other groups. Statistical analysis demonstrated that there was a significant increase between mean action of PCNA immune stain in control groups with pilocarpine subgroup and green tea subgroup at 15 days. On the other hand, there was no significant difference between control and MTX subgroup. At 30 and 45 days, there was significant increase between control group with MTX subgroup, pilocarpine subgroup and green tea subgroup.