الفهرس 
Introduction
Chapter I : Viral HepatitisOnly 14 pages are availabe for public view
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Abstract
Hepatitis C becomes a global health problem. New direct-acting has revolutionized HCV treatment. This study aimed to evaluate the diagnostic usefulness of HCV-NS4 Ag detection using ELISA in monitoring patients with chronic HCV-genotype-4 after antiviral therapy with DAAs. A total of 130 chronic hepatitis C patients showed both HCV-RNA and HCV-NS4 Ag in their sera and eligible for treatment were subdivided into two groups; group I (n=90) received DCV (60 mg) and group II (n=40) received SMV (150 mg) both in daily combination with SOF (400 mg) for 12 weeks. Baseline levels of HCV-NS4 Ag showed good correlation with HCV-RNA. The SVR12 rate based on HCV-NS4 Ag in both groups showed no significant difference with that of HCV-RNA. In conclusion, HCV-NS4 Ag detection by ELISA is a reliable and a simple method which can effectively replace or adjunct to RT-PCR in monitoring new DAAs therapy in chronic hepatitis C patients.