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العنوان
Effect of intrauterine injection of human chorionic gonadotropin on the outcomes of intracytoplasmic sperm injection /
المؤلف
Abdel-Fatah, Abdel-rahman Awad.
هيئة الاعداد
باحث / عبدالرحمن عوض عبدالفتاح
مشرف / محمد عبداللطيف النجيري
مشرف / احسان راغب رفاعي
مشرف / ياسر حمدي مصباح
الموضوع
sperm injection.
تاريخ النشر
2018.
عدد الصفحات
100 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
ممارسة طب الأسرة
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة المنصورة - كلية الطب - قسم التوليد وامراض النساء
الفهرس
Only 14 pages are availabe for public view

from 121

from 121

Abstract

The present study was designed to investigate the effects of higher dose (1000 IU) of intrauterine injection of hCG before the embryo transfer in ICSI cycles on pregnancy rate in comparison with standard dose (500 IU) or control.Results of the present work revealed that,• The studied females in the three groups were comparable as regard to age and BMI.• In addition, there was no statistically significant difference between studied groups as regard to type of infertility or protocol of induction. •Furthermore, no significant difference was found between 3 groups regarding AMH and E2 level.• No statistically significant difference was found between 3 groups regarding oocyte retrieved, fertilized ovum, transferred high quality embryos and endometrial thickness, M1 or M2, high quality embryos and number of gestational sacs.•Implantation rate was statistically significantly higher in HCG1000 group (39.3%) compared to HCG 500 group (29.8%) and control group (27.57).• In addition, chemical pregnancy was significantly higher in HCG1000 group (47.8%) compared to (14.3%) in control group and 23.5% in HCG 500 group. However, the difference between contorl and HCG500 was statistically non-signifcant.
• Finally, clinical pregnancy was statistically significantly higher in HCG1000 group (33.5%) compared to (11.1%) in control group and 17.6% in HCG500 group.Conclusion and recommendations Intrauterine injection of hCG before ET is of capability to improve the implantation and pregnancy rates in ICSI cycles. In addition, the resutls of the present work revealed that, the success rate is proportional to the dose of hCG used. Thus, it is recommended to use higher doses of hCG in routine work to increase the success rate. However, due to small number of cases included in the present work we recommend conducting large scale studies to confirm results of this study.Anyway, this method has some advantages: intrauterine injection of hCG is not expensive and is a cost-effective method in infertile women. Other advantage is that this method does not consume additional time for the clinical staff and does not require complex training. In addition, this intervention could be replicated by all units and could be considered to be without major risk. Hence, advantages of this method beside of positive effects of hCG to enhance pregnancy rate could make it as good intervention to treat infertile women.