الفهرس | Only 14 pages are availabe for public view |
Abstract This study was conducted to investigate the effect of dry rocket (Eruca sativa Mill.) and radish (Raphanus stivus, L) as 2.5% and 5% on hypercholesterolemic male albino rats induced by Triton-x-100 (100mg/kg of the weight of the rat). Also, determination of phenolics compounds of rocket and radish. The study included 40 rats, weight about 140-150g, each which divided into 8 equal group, two were kept as a control (-ve) and (+ve) groups, while, the other 6 groups were induced hypercholesterolemic by Triton-x-100 (100mg/kg of the weight of the rat). Body weight, feed efficiency ratio, feed intake, total cholesterol, triglycerides, lipoprotein fraction (HDL, LDL, VLDL, AI), glucose, kidney function (urea, uric acid and creatinine), serum liver function (ALT and AST) total biliruben, albumin ratio and hestopathological changes of liver, heart, kidney, spleen and pancreas, have been determined. The obtained results indicated that rocket, radish leaves and their mixtures contains different amount of phenolics compounds. Data also of rocket, radish leaves and their mixtures showed a significant in weight gain, feed intake, feed efficiency ratio, albumin level, TC, TG, HDL-c, LDL-c, VLDL-c, and all other parameters including internal organs weights were improved. The histopathological examination confirmed the improvement of biochemical parameters. As conclusion, rocket, radish and mixture of them could be considered powerful nutraceutical therapeutic means for the treatment of hypercholesterolemic rats. Key words: Hypercholesterolemia, Radish, Rocket, Rats, Phenolic compounds, Biochemical analysis. |