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العنوان
Evaluation of Relationship Between Nonalcoholic Fatty Liver and Coronary Artery Disease Severity by Multidetector Computed Tomography /
المؤلف
Khedr, Amirra Abd El-Ghany,
هيئة الاعداد
باحث / اميرة عبد الغنى خضر
مشرف / خالد اسماعيل الشافعى
مشرف / سامح احمد خضير
مشرف / تيمور مصطفى عبد الله
الموضوع
Radiodiagnosis.
تاريخ النشر
2018.
عدد الصفحات
152 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأشعة والطب النووي والتصوير
تاريخ الإجازة
20/6/2018
مكان الإجازة
جامعة طنطا - كلية الطب - Radiodiagnosis
الفهرس
Only 14 pages are availabe for public view

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from 190

Abstract

According to the report of the World Health Organization (WHO) in 2012, the CHD has been the most serious global health issue as it leading cause of morbidity and mortality worldwide. So in order to prevent or delay the progression of CHD, early detection of CHD status for asymptomatic individuals is required. Recently, nonalcoholic fatty liver disease (NAFLD) has become an emerging health problem with a prevalence of up to 30% in general population. Also NAFLD was thought to be a benign condition but now considered to be a major cause of liver-related morbidity and mortality. Studies reported that NAFLD may progress to cirrhosis, liver failure, and hepatocellular carcinoma. A series of previous studies suggested that NAFLD is associated with CHD, independent of traditional risk factors and other metabolic factors Therefore it can be hypothesized that NAFLD may associate with subclinical atherosclerosis. Our study aimed to assess the relationship between NAFLD and coronary artery disease severity. This study included 30 patients referred to diagnostic radiology and medical imaging department at Tanta University Educational Hospital from cardiology department and private clinics with symptoms suggestive of ischemic heart disease for evaluation by multislice CT angiography of coronary arteries during the period between February 2017 and February 2018. All the patients were subjected to detailed history taking, clinical examination, laboratory investigations and radiological examination including: Multislice CT angiography for evaluation of the coronary arteries. 2- Evaluation of the liver by: a) Non enhanced CT scan of the liver. b) Ultrasound evaluation of the hepatic steatosis. We found that NAFLD detected in 69.2% of the patient with documented CHD, the prevalence of NAFLD was 53.3% of the cases. Seventy percentages of the cases were female and thirty percentages were male .The age of the patients ranged between 33 and 78 years with significance of increased age in comparison between the patients with positive association between NAFLD and CHD and normal group also in comparing between this group and the patients with evident CHD without liver affection, there is also significance of BMI, diabetes mellitus between the group showing positive association between NAFLD and CHD and normal group but there is no significance for hypertension. We also found that 72.7 % of the cases with CACS>0 were associated with NAFLD and we also found that there is significant association between the coronary artery disease severity score (Gensini score) and grading of fatty liver infiltration (p value=0.017).