الفهرس 
SURGICAL SITE I NFECTIONOnly 14 pages are availabe for public view
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Abstract
I
nfection is a major complication of surgical procedures, and among surgical patients, surgical site infection (SSI) is the most common nosocomial infection. SSIs prolong hospitalization, increase the cost of care, and are associated with excess mortality.
Prevention of SSI is essential. Oxidative killing by neutrophils has been shown to represent a major defense against SSI.
Oxidative killing is enhanced by high oxygen tension in the tissues, which reduces the risk of SSI. Perioperative supplemental oxygenation to increase oxygen partial pressures in tissues has been studied as a means to reduce SSI.
Hence, most of the guidelines published recently for the prevention of SSI have included the use of high FiO2 perioperatively as a means for reducing the incidence of infection.
Yet, it remains a source of debate since most guidelines are based on evidences of moderate quality.
Several randomized controlled trials have been conducted over the years but none was conclusive regarding the benefit of hyperoxygenation on decreasing the incidence of SSIs.
Also, remains the controversery over using high FiO2 for its multiple side effects.
The aim of this study is to evaluate the effect of high inspired oxygen fraction supplementation on the incidence of surgical site infection in women undergoing elective abdominal hysterectomies compared to a group of patients receiving low inspired oxygen fraction supplementation intra-operatively
This prospective randomized controlled clinical trial study was conducted in Ain Shams University hospitals operating rooms after approval of the medical ethical committee. It included 226 adult female patients undergoing elective hysterectomy. They were allocated in two groups, 113 patient each:
group I: received 100% FiO2
group II: received 50% FiO2
The two groups were adequately monitored and assessed intra- and post-operatively and they were compared regarding incidence of surgical site infection during the 1st 7 days postoperatively.
The result of this study revealed that there was no difference in the incidence of post operative SSI in the hyperoxygenated group than the low FiO2 group.