الفهرس 
The keratinocyte-Melanocyte UnitOnly 14 pages are availabe for public view
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Abstract
Vitiligo is a common depigmenting skin disorder characterized by acquired, idiopathic, progressive, circumscribed hypomelanosis of the skin and hair with depigmented white areas on mucosal surfaces. Despite researches, the etiology remains unclear, but the theories regarding its pathogenesis include genetic, neural, cytotoxic, viral, growth factor, autoimmune, and oxidant-antioxidant theories. The complex Vitiligo pathogenesis might explain a wide spectrum of its systemic manifestations. The aim of this study was to estimate serum levels of (lipids and glutathione peroxidase activity) in patients with vitiligo and the correlations with clinical data and disease activity. This study included (60) patients with Vitiligo collected from the outpatient clinic of Dermatology and Venereology Department Tanta University Hospital. In addition to, (20) healthy individuals with matched age and sex served as a control group. All studied individuals were subjected to complete history taking, general and dermatological examination to exclude any systemic or dermatological diseases, ocular and audiological examination to exclude any associations, Wood’s lamp examination, photographs to the affected sites. Diabetes mellitus, BMI more than 30 and any systemic disease were excluded from complete laboratory investigations. VASI and VIDA scores were assessed. Serum levels of (lipid and GPx activity) were estimated. Written informed consent was taken before starting. The results of this study are summarized as the following:- The mean age of vitiligo patients was 29.95 ± 14.45.While in control group, it was 29.35 ± 16.94. BMI in patients, the mean was 24.60 ± 2.79. While in control it was 24.17 ± 2.87. The duration of the disease in segmental vitiligo group was with a mean of 5.67 ± 8.67 years. While in the non-segmental group it was 4.04 ± 6.07 years. Family history of segmental vitiligo group was positive in 2 patients (13.3%) while in non-segmental vitiligo, it was positive in 16 patients (35.6%). Serum levels of cholesterol, triglycerides, low-density lipoprptein (LDL), very low-density lipoprptein (VLDL) showed a statistically significant increase in vitiligo patients (both segmental and nonsegmental groups) compared to control group. Serum level of high-density lipoproteins showed a statistically significant decrease in vitiligo patients (both segmental and nonsegmental groups) compared to control group The LDL/HDL ratio showed a statistically significant increase in vitiligo patients (both segmental and non-segmental groups) compared to control group In segmental group: Statistically significant positive correlations between serum level of cholesterol and BMI, VASI% and VIDA score. A statistically significant positive correlation between serum level of triglycerides and VASI%. Statistically significant positive correlations between serum level of LDL with age and VIDA. A statistically significant positive correlation was found between serum level of VLDL with VASI%. In non-segmental group:- Statistically significant positive correlations between serum level of cholesterol and BMI, age, duration, VASI% and VIDA score. Statistically significant positive correlations between serum level of LDL with BMI, disease duration, VASI%, age and VIDA score. Statistically significant positive correlations between LDL/HDL ratio with disease duration, VASI%, age and VIDA score.Activity in vitiligo patients showed statistically significant positive correlation with serum level of cholesterol and LDL in both segmental and non-segmental groups and with LDL/HDL ratio in the nonsegmental group. Serum GPx activity level showed a statistically significant increase in vitiligo patients (both segmental and non-segmental groups) compared to control group. But the correlations between serum activity level of GPx and clinical data including (activity, age, sex, duration, VASI, VIDA) and lipid profile in each group were statistically non-significant.