الفهرس 
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Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common inherited disorders of mankind; more than 400 million people are affected worldwide, especially in tropical Africa, the Middle East, tropical, subtropical Asia and the Mediterranean basin. In Egypt which considered as a Mediterranean country the incidence reaches up to 9.4%.
The clinical manifestations of G6PD deficiency vary from no symptoms to neonatal jaundice, chronic nonspherocytic hemolytic anemia and severe acute hemolytic anemia induced by infection, drug intake or fava beans ingestion. The latter stood for the most frequent single cause of hospital admissions due to a hematological disease in Egypt.
So our aim in this study was to detect some predictors of severe hemolysis and the degree of DNA damage in children with G6PD deficiency presented with acute intravascular hemolysis, theses predictors may be at history, symptoms, signs or laboratory findings.
The present study included 72 patients, 52 patients had severe hemolysis (Hb ≤ 5 g/dl) and a control group of 20 patients had mild to moderate hemolysis (Hb > 5 g/dl). All the cases are subjected to full history, detailed clinical examination and the following laboratory investigations: G6PD enzyme level (for whom were newly diagnosed), presence of DNA damage, complete blood picture including hemoglobin concentration and reticulocytic count%, in addition to levels of alkaline phosphatase enzyme, total and direct bilirubin, alanine transferase enzyme, aspartate transferase enzyme and lactate dehydrogenase enzyme.