الفهرس | Only 14 pages are availabe for public view |
Abstract Summary Diabetes mellitus is one of the most common metabolic disorder which affects multiple organs and systems. NAFLD is a common complication of DM that may cause hazards to the liver such as steatosis, steatohepatitis & fibrosis and may lead to liver cirrhosis with long term disease. Our comparative cross- sectional study aimed at using fibroscan which is a non-invasive technique for assessment of liver steatosis & fibrosis in diabetic patients. For the purpose of the study 60 patients were included and they were classified into 3 groups as following: group (I): Included forty diabetic patients who were subdivided into 2 subgroups: group IA with obesity and group IB without obesity. group (II): Included twenty patients with obesity but without diabetes as controls. Patients and controls were subjected to the following assessment: Thorough personal, present and family history taking Complete clinical examination: particularly for acanthosis negricans, psychological disorders, neuropathy and hypertension. Laboratory investigations including: FBG, 2 hours post prandial blood glucose, lipid profile, liver function tests, blood urea, serum creatininc, CBC, CRP and ESR. Pelvi –abdominal us. Fibroscan. The following results were obtained: Steatosis was higher in diabetic patients when compared with patients with obesity only (controls). Steatosis was higher in diabetic patients with central obesity than diabetic patients without obesity. Fibrosis was higher in diabetic patients with obesity than controls. Positive correlation in group IA between steatosis and serum triglycerides. Positive correlation in group IA between fibrosis and the following parameters: triglycerides, body mass index and fasting blood glucose. Positive correlation in group IB between fibrosis and duration of diabetes mellitus. |