الفهرس 
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Abstract
Fifty-four new compounds, that are not previously stated in any literature, were synthesized via six different schemes in the first part. All Reactions were monitored using TLC plates and the target compounds were purified either by silica gel column chromatography, preparative TLC or recrystallization. The structure elucidation of the new compounds was checked based on spectra analyses, IR, 1H NMR, 13C NMR, and high resolution mass spectrometry. All the newly synthesized compounds were subjected to MTT anticancer screening against human cell lines; breast adenocarcinoma (MCF-7), colon cancer (HCT-116), cervical epithelial cells (Hela), and hepatocellular carcinoma (HePG-2). Some promising compounds were selected for in vitro inhibition of Epidermal Growth Factors Receptor kinase (EGFR-TK) and topoisomerase II enzymes. In addition, some selected compounds were subjected to cell cycle analysis and apoptosis assay on MCF-7 cells. While in the second part, efforts on the development of the synthesis and application of diazonaphthoquinone chemistry were explained. In addition, the first total synthesis of Eleutherol and Eleuthoside A, the natural cytotoxic substances extracted from medicinal Indonesian plant, was accomplished via Rh-catalyzed intramolecular cyclization of the corresponding diazonaphthoquinone.