الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Sepsis remains the primary cause of death in intensive care unit (ICU) patients despite improvements in antibiotic and early hemodynamic management. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as a subset of sepsis in which underlying circulatory and cellular metabolism abnormalities are profoundenough to substantially increase mortality.
Oxygen must be regarded as any other drug with potential dose and time depended side effects. Oxygen administration is the most widely prescribed therapy in critically ill patients and frequently represents a life-saving intervention. Since hypoxemia is generally viewed as deleterious and moderate levels of arterial hyperoxia as benign, health care practitioners are more likely to accept supranormal arterial O2 levels as this provides a wider safety buffer.
The aim of this work was to investigate whether hyperoxia is associated with higher mortality in septic shock patients. This study was carried out on 200 septic shock patients .After fulfilling the criteria ,the following data were collected and recorded: The demographic data ,Clinical data,Severity scoring systems,Clinical and microbiological cause of sepsis,Laboratory investigations,Ventilatory data, Oxygenation status data,days of mechanical ventilation, length of hospital stay and the patient outcome .
The studied patients were classified in the end of the study into two groups: group I (the non hyperoxic group) that included 40 patients who were exposed to PaO2 <120mmHg and group II (the hyperoxic group) that included 160 patients who were exposed to PaO2 >120mmHg.
We divided the group IIinto two subgroups , a group ofmoderate hyperoxia which included 118 patients who were exposed to PaO2 120 – 300 and a group of severe hyperoxiawhich included 42 patients who were exposed to PaO2>300 .
After analyzing the data , the following results were obtained:
• In group I: mean number of days of mechanical ventilation was of 5.25 ± 1.81day , while in group II: mean number was of 11.38 ± 5.27 day.
• In group I: mean number of days of ICU stay was of 8.88 ± 3.31 day,while in group II: mean number was of 13.14 ± 5.39 day.
• In group I: mean number of days of hospital stay was of 11.18 ± 3.74 daywhile in group II: mean number was of 13.55 ± 5.11 day.
• In group I, 23 patients (57.5%) were discharged and 17 patients(10.6%) were died. While in group II, 17 patients (42.5%) were discharged and 143 patients (89.4% ) were died.
• In subgroup of moderate hyperoxaemia,16 patients (94.1%) were discharged and 102 patients(71.3%) were died. While in subgroup of severe hyperoxaemia, 1 patient (5.9%) was dischargedand 41 patients(28.7%) were d