الفهرس | Only 14 pages are availabe for public view |
Abstract This study was conducted on forty patients with an incidentally discovered diffuse fatty liver by US. And twenty asymptomatic patients as a control group (10 were men). The overall mean age was the mean age was 45.35 ± 3.34 (range, 40– 50years). The aim of the study was to investigate the association of Non-alcoholic fatty liver disease with carotid intima-media thickness (CIMT) and plaque as surrogate measures of increased cardiovascular risk. All Patients in this study were subjected to thorough history taking including age, sex and medical history, full clinical examination including vital signs, general examination, measurements of weight, standing height and BMI, real time abdominal US , and virtual touch TM quantification for the liver and CIMT measurement. Participants were investigated for total cholesterol, triglycerides, high-density lipoprotein, fasting plasma glucose were analyzed and low density lipoprotein was calculated using Friedwald equation. The highest recorded measurement for the carotid intima media thickness in our cases group was 9 mm while the control group maximum value was 7 mm with resulting p value of 0.001 denoting a significant correlation between CIMT measurements and the existence of fatty liver. Statistically significant positive correlation was found between the BMI and hepatic steatosis. Over 60% of the cases group were fibrosis grade f2 and none of them were grade f4 and 100 % of the control group were f0-f1 group; however we found no significant positive correlation between the grade of fibrosis and the measurement of CIMT with a p value of 0.604. Regarding the ultrasound grade of fatty liver in the cases group over 50% were grade 2; however we found no significant correlation between the CIMT and the grade of fatty liver with a p value of 0.596, But it should be put in consideration that a 1 mm increase in CIMT increases the chance of a cardiovascular incident dramatically. So even though there was no statistical correlation, clinically it is quite relevant and a 1 mm increase in CIMT should be addressed attentively. |