الفهرس 
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Abstract
Background: Breast cancer is the commonest cancer among women, accounting for approximately 26% of all incident cancers among women. Surgery is the main line of treatment of breast cancer, lumpectomy followed by radiation is standard treatment for early breast cancer. This study was conducted prospectively on 54 female patients diagnosed with early-stage breast cancer (stage I and II) between March, 2016 and February, 2018 who were eligible for BCS who had been admitted to Alexandria University Hospitals with exclusion criteria of any contraindication to BCS or Patient´s refusal of breast conserving surgery. Patient age, preoperative investigations, surgery, and margin status were examined using computerized database. Univariate analysis was performed to identify patient and tumor factors predicting the margin status. The results were used to generate a patient selection algorithm.
The rate of positive margins at resection was 48% in 26 lumpectomies. Univariate analysis revealed that older age (P = 0.031), smaller tumor size (P = 0.009), negative axillary LN metastasis (P <0.001), grade I (P <0.001), and II (P <0.001), ER positive tumors (P <0.001), type of techniques (ultrasound -guided wire localization, P = 0.020) were predictive for having a negative margin. While young age (P = 0.031), large tumor size (P = 0.009), positive LN metastasis (P <0.001), microcalcification (P = 0.012), multifocality (P = 0.043), ILC (P = 0.003), EIC (P =0.031), grade III (P <0.001), ER negative tumors (P <0.001), Her 2 receptor over expression (P <0.001), and TNBC (P = 0.031) were predictive for having a positive margin.