الفهرس 
Diabetic NephropathyOnly 14 pages are availabe for public view
 |  | from | 188 |  |  |
| | | from | 188 | | |
Abstract
ABSTRACT
Background: Our study was a cross sectional study aimed to assess the role of urinary nephrin as an early biomarker for diabetic nephropathy in patients with type 2 diabetes mellitus. We measured urinary nephrin in 75 patients with type 2 DM. Patients were divided according to albumin/ creatinine ratio into 3 groups (25 normoalbuminuric patients, 25 microalbuminuric patients, 25 macroalbuminuric patients) and they were compared to 15 healthy control subjects.
Objective: To evaluate the role of urinary nephrin as an early biomarker for diabetic nephropathy in patients with type 2 diabetes mellitus.
Patients and Methods: We compared those three groups (normoalbuminuric, microalbuminuric and macroalbuminuric groups) as regard demographic data, laboratory results and clinical parameters. We excluded patients with other causes of proteinuria or podocytopathy rather than diabetic nephropathy.
Results: Our results show that there was no significant difference between study groups as regard sex, age and blood pressure. We found in our study that urinary nephrin was higher in all patients groups than control group, with macroalbuminuric group had the highest level, and normoalbuminuric group has the lowest level in patients group, but still significantly higher than control group. We found also that there was a positive correlation between urinary nephrin levels and the degree of albuminuria in all patients and in different groups including normoalbuminuric group.
Conclusion: We also compared between different study groups as regard estimated glomerular filtration rate (eGFR) (using MDRD and COCKCRAFT), this showed that macroalbuminuric group had lower eGFR than normoalbuminuric group, while there was no significant difference in eGFR between microalbuminuric group and the other two groups. (Why writing the last part with conclusion NOT with results???)