الفهرس 
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Abstract
Non-Hodgkin’s lymphoma (NHL) is a heterogeneous group of malignancies that originate in lymphatic hematopoietic tissue . According to different types of lymphoid cells , NHL is further classified into B-cell lymphomas which account for about 90% and T-cell lymphomas which are about 10%.
MicroRNAs (miRNAs) are a class of single-stranded non-coding RNA molecules of 19–24 nucleotides that control gene expression at a post-transcriptional level. They derive from the metabolic processing of long RNA transcripts encoded by miRNA genes. They have been detected in plants, animal species and viruses, and are involved in numerous cellular processes including proliferation, differentiation, apoptosis and metabolism .
MicroRNA-155 is produced from the processing of the B-Cell Integration Cluster (BIC), which is a non-coding transcript expressed in activated B cells, T cells, monocytes and macrophages .High expression of microRNA-155 indicates poor prognosis in CLL and DLBCL.
This study had been carried on 40 patients suffering from NHL ,They were 23 males and 17 females, their ages ranged from 20 to 79 years, and ten apparently healthy subjects as control of matched age and sex in the period from December 2015 to Mars 2016.
Patients and control were classified into two groups:
group І (Patients group ):
This group consists of 40 diagnosed adults with Non-Hodgkin lymphoma . This group included 23 males (57.5%) and 17 females (42.5%).
This group was sub-classified into four groups:
1-group IA: 20 diffuse large B-cell lymphoma (DLBCL).
2-group IB: 15 chronic lymphocytic leukemia ( CLL) .
3-group IC: 3 follicular lymphoma (FL) .
4-group ID: 2 Burkitt lymphoma (BL).
group ІI (Control group):
They were ten apparently healthy subjects, matched for age and sex with patient group. Their ages ranged from 24 to 75 years with mean ± SD 45.2±15.73 and this group included 4 males(40%) and 6 females (60%).
All patients were diagnosed on the bases of clinical features, cell morphology in peripheral blood film and B.M, cytochemistry for some cases, and histopathological analysis of lymph node biopsy.