الفهرس | Only 14 pages are availabe for public view |
Abstract Congenital heart defects (CHDs) are the most common type of birth defect. As medical care and treatment have advanced, infants with congenital heart defects are living longer and healthier lives. Many now are living into adulthood. Nephropathy is a well known complication of congenital heart disease and the risk of developing renal impairment is particularly high in patients with cyanotic congenital heart disease. Although this complication occurs with long duration of disease, however tubular injury may occur even in the first decade. This study aimed to assess the glomerular and the tubular renal dysfunction in cyanotic and acyanotic CHD in infants and children. Our study was carried out on sixty child that subdivided into 18 cyanotic CHD ,22 acyanotic CHD and 20 apparant healthy children as acontrol. The studied children were subjected to complete medical history,full clinical and radiological examination and Laboratory investigations which include: (Renal function: serum creatinine and blood urea), Glomerular filtration rate (GFR), Urinary albumin/ creatinine ratio, Urinary microalbumin and Urinary beta2microglobulin. In our study we found that there were no statistically different between cyanotic and acyanotic patients group and control groups as regard age, sex, weight and height. In addition we found that the CHD groups had significantly higher level of blood urea, serum creatinine, A/C ratio and B2-microglobuline and significantly lower eGFR in CHD groups than in control groups. Furthermore we found that the cyanotic groups had significantly higher level of blood urea, serum creatinine, A/C ratio and B2-microglobuline and significantly lower eGFR in cyanotic groups than in control groups. In addition we found that the acyanotic groups had significantly higher level of blood urea, serum creatinine, A/C ratio and B2-microglobuline and significantly lower eGFR in acyanotic groups than in control groups. Also we found that the cyanotic groups had significantly higher level of blood urea, serum creatinine, A/C ratio and B2-microglobuline than acyanotic groups and significantly lower eGFR in cyanotic groups than in acyanotic groups. There were almost no significant correlation between B2-microglobuline and both eGFR and A/C ratio in cyanotic, acyanotic and control groups. |