الفهرس 
Aging and Cardiovascular SystemOnly 14 pages are availabe for public view
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Abstract
Aging is a major risk factor for the most important age-related diseases including coronary, peripheral, and cerebrovascular artery disease.
Pulmonary hypertension is a substantial global health issue. All age groups are affected with rapidly growing importance in elderly people, particularly in countries with ageing populations.
Aim of the study was to evaluate the effect of aging on resting pulmonary artery systolic pressure non-invasively using TTE.
We recruited 200 elderly patients referred for echocardiographic evaluation at Heliopolis and Ain Shams University Hospitals in the period from August 2017 to February 2018 .After a detailed history, all patients were assessed clinically followed by M-Mode and 2D echocardiographic assessment, pulsed and continuous wave Doppler for routine examination. RVSP was calculated from the peak tricuspid regurgitate jet velocity (V) using the modified Bernoulli equation (RVSP = 4V2 + RAP), with the mean right atrial pressure (RAP) estimated to be 10 mmHg.
While Mean PA pressure = 79 (0.45 x AT), where acceleration time (AT) being measured from PW Doppler on pulmonary valve in short axis aortic level.
Our data showed that 47% of patients had PASP >35 mmHg and 24% had PASP>40 mmHg. Systemic hypertension was prevalent among patients with abnormal PASP. Most of patients had grade I diastolic dysfunction (92%) that showed a non -significant correlation with pulmonary artery pressure. Only 3% of patients had severe form of dysfunction. There was a highly significant positive correlation between age and PASP.
Pulmonary artery systolic pressure was higher than the expected normal values (35 mmHg) in 47% of patients above 60 years of age and this dropped to 24% when 40 mmHg was used as the cutoff value for normal level. Mild degree of diastolic dysfunction was prevalent among the study group and only 3% had severe form of dysfunction. There was no significant correlation with PASP. No gender predilection of abnormal PASP in the aged population. Systemic hypertension was prevalent among patients with abnormal PASP. Pulmonary artery systolic pressure showed a significant direct correlation with age.