الفهرس 
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Abstract
Gentamicin is an effective, widely used aminoglycoside antibiotic against severe and life-threatening infections, but the risk of nephrotoxicity and oxidative damage limit its clinical use. Hence, the subject of our work was to explore the alleged ameliorative effect of both calcium acetate and quercetin on gentamicin-induced acute nephrotoxicity depending upon their different mechanisms of action on the renal tissues, comparing the effects of different dosages of calcium and different administration regimen of quercetin on gentamicin-induced nephrotoxicity in rats.
Seventy, apparently healthy, male albino rats weighing 150- 200 gm were employed in this study. Rats were randomly classified into seven equal groups; each of 10 rats. First group (G1) served as control group and injected with normal saline, intraperitoneally, second group (G2) was injected with gentamicin (80 mg/kg/d, intraperitoneally for 7 successive days), third group (G3) was simultaneously treated with gentamicin plus lower dose of calcium acetate (75 mg/kg/d, orally for seven consecutive days), fourth group (G4) was simultaneously treated with gentamicin plus higher dose of calcium acetate (200 mg/kg/d, orally for seven consecutive days), fifth group (G5) was treated with gentamicin; afterwards, rats were treated with quercetin (50 mg/kg/d, orally for seven consecutive days, sixth group (G6) was treated with quercetin; afterwards, rats were simultaneously treated with gentamicin plus quercetin, and seventh group (G7) was simultaneously treated with gentamicin, calcium acetate (lower dose), and quercetin.