الفهرس 
Alopecia AreataOnly 14 pages are availabe for public view
 |  | from | 112 |  |  |
| | | from | 112 | | |
Abstract
Abstract
Abstract
Background: Alopecia areata (AA) is a common non-scarring loss of scalp hair in well demarcated round or oval patches. Vitiligo is an acquired depigmentation disorder characterized by selective destruction of melanocyte and manifests by white macules or patches. IL-17 is a proinflammatory cytokine which is involved in the pathogenesis of AA and vitiligo.
Aim of the work: The aim of this study was to detect IL-17 gene expression and its plasma protein level in AA and vitiligo patients.
Subject and methods: This case-control study included 25 AA patients, 25 vitiligo patients and 25 apparently healthy controls. Plasma IL-17 level was measured by ELISA technique and IL-17 gene expression was investigated by real time PCR.
Results: Plasma IL-17 and its gene expression levels were significantly higher in AA patients than in each of vitiligo patients and controls. There was also a statistically significant difference of Plasma IL-17 and its gene expression levels between vitiligo patients and controls.
Conclusion: This study suggests that an increase in Plasma level of IL-17 in AA and vitiligo patients may play an important role in the aetio-pathogenesis of both diseases. The increase of IL-17 gene expression may confer susceptibility to AA and vitiligo diseases.
Key words: AA, IL-17, IL-17 gene expression, vitiligo.