الفهرس 
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Abstract
Liver cancer is the sixth most common cancer and the third cause of cancer related deaths. In Egypt, hepatocellular carcinoma (HCC) has become the second most prevalent cancer among men.Detailed analysis & characterization of molecular, genetic & epi-genetic events would revolutionize early diagnosis of HCC.Gene & protein expression profiling will allow better screening of different stages of HCC as well as establishment of criteria for targeted therapies.The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) gene is a novel transformation suppressor gene against activated oncogenes.Downregulation of RECK is documented in a wide range of malignant neoplasms (e.g. pancreatic cancer, breast cancer…etc.) and correlates with poor prognosis & tumor metastasis.The aim of this work was to study the association between RECK gene polymorphism and the development of hepatocellular carcinoma in patients with liver cirrhosis.This study was conducted on 115 individuals. The patients were recruited from outpatient clinic and/or inpatient Department of Hepatology, Gastroenterology & Infectious Diseases, Benha faculty of Medicine, and from the outpatient clinic of the National Research Center.