الفهرس 
Title pageOnly 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
Infertility is a major health problem that is estimated to affect 15-20% of couples worldwide. It was estimated that 40% of infertility cases are due to female factors, 40% are due to male factors, and 20% are due to combined male and female factors or due to infertility of unknown etiology. The advent of ICSI in conjunction with PGD has revolutionized the treatment of men with severely compromised semen parameters and improved their chances of achieving normal term pregnancy. This is because ICSI greatly reduces the requirements for semen quality, motility and fertilization ability, while PGD enables the analysis of chromosomal complement of embryos of infertile men allowing the transfer of only chromosomally normal embryos, thus improving success rate and eliminating potential risks of using suboptimal sperms for fertilization.
The study was performed on forty two couples who were divided into two groups; patients with severe and moderate teratospermia (group A and B respectively)
All patients were subjected to careful history taking, complete clinical examination. Female patients were subjected to hormonal assays, pelvic ultrasound, hysterosalpingography, ovulation induction and follicular aspiration, while male partners were subjected to computerized semen analysis.
Intracytoplasmic sperm injection was performed microinjection of preselected sperms into the cytoplasm of only mature oocytes that extruded their first polar bodies.
Preimplantation genetic diagnosis was performed for all suitably developed embryos including embryo biopsy , fixation of biopsied cells and fluorescent in situ hybridization (FISH) analysis which revealed a threefold increase in the incidence of sex chromosomal aneuploidy in embryos of patients with severe teratospermia when compared to patients with moderate teratospermia.