الفهرس 
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Abstract
The current study was conducted to study the effect of endocrine disruptors (e.g. DBP) on the testicular development and to screen the possible ameliorative role of selenium nanoparticles (Se-NPs) against it in pre- and post-pubertal male rat offspring. Forty-two pregnant female rats treated from gestation day (GD) 12 to postnatal day (PND) 14 day with two doses of Se-NPs (0.2 and 0.5mg/kg/d) against developmental testicular toxicity induced by DBP (500mg/kg/d). At PND 25 (pre puberty) and 60 (post puberty), blood and testes of offspring were collected. Relative testicular weight, total serum testosterone, oxidative stress biomarkers, malodialdehyde (MDA( and reduced glutathione (GSH), relative genes expression for some growth, steroidogenic, antioxidant and apoptotic related genes were evaluated in all groups. The epigenetic changes as methylation analysis of cytochrome C (c-myc) and mineralocorticoid receptors (MR) gene promoters and histopathological examination were also estimated in all groups. The obtained results revealed that maternal exposure to DBP significantly disrupt the growth, steroidogenesis, antioxidant, apoptosis and DNA methylation. The histopathological changes include necrosis and desquamation of spermatogoneal cells at PND 25 and complete loss of spermatogenesis at PND 60. These effects were improved by administration of high dose of Se-NPs. In conclusion, Se-NPs could be a promising prophylactic agent for the dam during gestation and lactation periods to compete against endocrine disruptors (e.g. DBP).