الفهرس 
Physical & Chemical characters:
Oxidative StressOnly 14 pages are availabe for public view
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Abstract
Pesticides constitute a broad group of substances that are
designed to kill, reduce or repel insects, weeds, rodents, fungi and
other organisms that can threaten public health and national
economies. Acute poisoning with pesticides is a global public health
problem and accounts for many deaths worldwide every year.
In Egypt, there is higher incidence of exposure to phosphides.
Being cheap, widely available and highly toxic, it is responsible for
many cases of poisoning with high morbidity and mortality.
L-carnitine (LC) has a prominent antioxidant activity.
Research interest in LC has grown due to increased evidence of the
role of oxidative stress in acute phosphide poisoning. However, LC is
able to act as a direct scavenging agent of oxygen free radicals.
Metal phosphide poisoning has no specific antidote, therefore,
based on role of oxidative stress in metal phosphide poisoning, this
study was conducted to evaluate efficacy and safety of L-Carnitine
(LC) as an adjuvant therapy in management of patients with acute
phosphide poisoning.
This study was a randomized clinical trial. It was conducted in
Poison Control Center (Emergency Hospital, Tanta & Mansoura
University). Fifty acute phosphide intoxicated patients were
randomly allocated into two equal groups I and II using the
sequentially numbered, opaque sealed envelopes method. group I:
patients exposed to acute phosphide poisoning received standard
treatment. group II: patients exposed to acute phosphide poisoning received standard treatment in addition to L-carnitine (1 gm/8 hours
intravenous).
All patients were subjected to:
I. Full history taking with emphasis on:
Age, gender, occupation, level of education.
Circumstances of poisoning whether intentional or
accidental.
Route(s) of exposure whether oral, inhalation or dermal.
Time elapsed before hospital admission.
II. Complete physical examination including:
Level of consciousness by Glasgow coma scale.
Regular monitoring of vital signs (pulse, blood pressure,
respiratory rate, and temperature).
III. Investigations including:
Arterial blood gases.
Serum sodium and potassium.
Kidney function tests (blood urea and serum creatinine).
Liver function tests (serum AST and ALT).
Serum malondialdehyde (MDA) level.
Serum reduced glutathione (GSH) level.
Serum total antioxidant capacity (TAC) level.