الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Backgound: Breast cancer is the most common cancer in woman worldwide and is the leading cause of cancer related deaths in developing countries, with nearly 1.7 million new cases diagnosed in 2012 (according to the latest date for available data). Global cancer rates in general are expected to rise from 14 million in 2012 to 20 million over the next two decades, making cancer a significant global health emergency.
Molecular subtyping confirms that breast cancer comprises at least four genetically distinct entities based on the expression of specific genes including estrogen receptor (ER), progesterone receptor (PR), and HER2/neu receptor. The quantitative influence of subtype on ipsilateral locoregional recurrence (LRR) is unknown.
Aim: To determine the prognosis of HER2 +ve neu breast cancer regarding local recurrence in patients trearted with breast conservative surgery vs Modified Radical Mastectomy.
Methodolgy: Retrosoective comparative study of 50 HER2 +ve neu patients treated with breast conservative surgery and 50 patients treated with Modified Radical Mastectomy. Type of study: Retrospective study. Study setting: Ain Shams University Hospitals. Study period: The past 5 years.
Study popultion: Patients were divided into two groups: group A: HER2 neu patients underwent conservative surgery. group B: HER2 neu patients underwent Modified Radical Mastectomy
Results: In our study there was no statistical significant difference between breast conserving surgery and modified radical mastectomy as regard local recurrence in HER2/neu cancer breast patients.
Conclusion: Modified radical mastectomy and breast conserving surgery as primary surgical treatment of cancer breast in HER2 ney patients have no favorable outcome over each other as regard local recurrence, and the decision of the type of surgery should be taken by discussion between doctor and patient as regard advantages and complications of each type.