الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Liver fibrosis represents a health problem with significant morbidity and mortality that affects 100 million people worldwide. Fibrosis is considered one of the most serious sequels of several chronic liver diseases and is associated with a number of pathological and biochemical changes leading to structural and metabolic abnormalities, as well as increased hepatic scarring. The progression of liver fibrosis leads to cirrhosis, a condition characterized by distortion of the normal architecture, nodule formation, altered blood flow, portal hypertension, hepatocellular carcinoma and ultimately liver failure.
In this setting, the present study aimed to recognize and compare effects of EUG and TEL on biochemical abnormalities, inflammatory status and iNOS pathway that account for the development of liver fibrosis and may act to exacerbate its complications.
The animals used in this study were 100 male Wister strain albino rats weighing 180-200 g. These animals were divided randomly into 10 groups, one of which served as a normal control group. Other 3 groups served as control EUG.10, control EUG.100 and control TEL. The remaining 6 groups were assigned to different treatments and were administered CCl4 (1 ml/Kg, i.p. ) in a ratio of 1:1 with olive oil twice weekly for 6 weeks for induction of liver fibrosis. Thus the study consisted of 10 experimental groups, - This is the first time to indicate that, the potential effectiveness of TEL in a model of hepatic injury induced by carbon tetrachloride in rats can be based on the modulation of iNOS pathway.
- Moreover, it is the first time to demonstrate the synergistic interaction between EUG and TEL, as the effect of using the drugs studied in bivalent mixtures of EUG (10 mg/kg/day), TEL (10 mg/kg/day) or EUG (100 mg/kg/day) and TEL (10 mg/kg/day) was better than the effect of each drug alone, and this indicates that the use of these drugs as a binary mixture often results in better results.
- In the present study, it was found that EUG in the low dose (10 mg/kg) had a slightly lower or equal effect with that of the high dose (100 mg/kg) in hepatic injury induced by carbon tetrachloride in rats. So, we recommend the lower doses to be used in order to reduce the cost and limit the risk of the adverse effects that may follow this regimen.
- Modulation of inducible nitric oxide synthase (iNOS) pathway might represent a potential therapeutic approach for liver fibrosis.
- Lastly, the important findings reached in the present study on rats encourage further confirmatory studies in near future to substantiate the use of the dual combination of EUG with TEL as a new approach for controlling liver fibrosis and its associated complications.