الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 190 |  |  |
| | | from | 190 | | |
Abstract
Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age leading to irregular menses, hirsutism, insulin resistance and infertility. Fenugreek (Trigonella foenum-graecum) is an important medicinal agent that has antidiabetic and antiandrogenic properties. This study aims to evaluate the effect of fenugreek seed extract in Letrozole induced PCOS in female albino rat. Thirty adult female albino rats were divided into five groups (six rats each) : group 1(Control group) received no medication.group 2 received vehicle only (oral doses of 2ml/kg body weight of 1% aqueous solution of Carboxy Methyl Cellulose once/day for 21 days). group 3 (Fenugreek treated group): were received oral doses of 100 mg/kg body weight fenugreek seed extract once/day for 21 days. group 4 (Letrozole treated group): were received Letrozole orally at a dose of 1 mg/kg dissolved in 1% (CMC) once/day for 21 days. group 5 (Letrozole + Fenugreek treated group): received Letrozole orally at a dose of 1 mg/kg dissolved in 1% (CMC) once/day for 21 days. Then rats were supplemented with oral doses of 100 mg/kg body weight fenugreek seed extract once/day for another 21 days. At the end of the experimental period, all animals were sacrified and both ovaries were excised and specimens were processed for light microscopic examination. Our results revealed that group 4 showed picture of polycystic ovary in the form of multiple ovarian cysts with a diminished granulosa layer, atretic follicles and a few number of corpora lutea. This picture was reversed after Fenugreek supplementation, there was marked improvement and disappearance of these cysts and increased number of corpora lutea were seen suggesting ovulation. Follicles at different stages of maturation were observed.
Conclusion, Fenugreek seed extract found to have a good potential as a curative therapy in the treatment of PCOS.