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Abstract Successful long-term results of dental implants have led to an increase in their usage in many clinical situations. Since the introduction of osseointegrated implants for the rehabilitation of edentulous patients, tremendous awareness and subsequent demand have arisen in the field, where implant supported fixed prosthesis became widely accepted as an alternative to conventional prosthesis. However, some clinical studies have reported variable rates of failure. Biomechanical factors and stress distribution around implant supported restorations are the prime factors leading to failure of implants. The relationship between load factors and implant failure cannot be ignored any longer because of the high incidence of fractures of components, marginal bone loss, and loss of Osseointegration in situations of compromised prosthetic reconstruction and/or extreme load conditions. The current study evaluated the effect of platform switching implants and different abutment materials (Titanium and zirconia) on the stress distribution around Implant supported monolithic full anatomical zirconia crowns. Stress analysis was measured using mechanical loading test together with strain gauge. The following materials were used in the current study: Implant direct dental implant fixtures. Implant direct titanium abutments. Implant direct Zirconia abutments. inCoris TZI mono blocks. . Epoxy resin material. Electrical resistance strain gauges Two implants were fixed in two anatomically correct mandibular epoxy resin models restoring posterior missing first molar. Twenty fullanatomical monolithic zirconia crowns were constructed over 4 sub-groups as follows: 1. Standard implant-abutment connection with titanium abutment 2. Standard implant-abutment connection with zirconia abutment 3. Platform switching implant-abutment connection with titanium abutment 4. Platform switching impant-abutment connection with zirconia abutment All zirconia crowns were fabricated by CAD/CAM technology. Full anatomical Zirconia crowns were milled using Cerec Inlab system. Cementing device was used to cement the crowns to its corresponding abutment using temporary cement. Strain was developed around the implants during static loading with a defined force of 300 N applied to the crown by a universal testing machine, they were measured using strain gauges at the buccal, the lingual, the mesial and the distal surfaces along with the long axis of implants. Measurements were carried out together with specialized software to analyze the strains that occurred. Within the limitations of this study, the following conclusions were drawn as follows: 1. The highest strain was observed in the groups with Standard implantabutment platform in comparison with the other groups with platform switching. 2. Regarding the effect of abutment material within the regular platform and platform switching groups, there was no statistically significant difference in strain development between the two abutment matertials. 3. The use of platform switching concept might be a successful approach to overcome bone resorption, due to shifting of stresses away from the bone-implant interface especially in high stress areas. 4. The abutment material has no influence on the strains induced in the supporting structures. Both Zirconia and titanium abutments could withstand the functional loads developed during physiologic chewing in the molar area. Zirconia abutments could be considered as a valid esthetic alternative to titanium abutments |