الفهرس 
PREMATURE I NFANTSOnly 14 pages are availabe for public view
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Abstract
The present study was performed on neonates admitted in Ain-Shams University NICUs from May 2017 till May 2018. Patients were enrolled randomly in the study after consideration of inclusion and exclusion criteria and obtaining an informed consent from the parents or care-givers.
The primary aim is to evaluate the efficacy of 1,3 B d Glucan in diagnosis of invasive fungal infection in neonates.
Secondary aim is to study the prevalence and risk factors of IFI in neonates.
The incidence of fungal growth in the studied preterm neonates admitted to our NICU during the period of our study was 9.3 %.
Results revealed that there is a highly significant relationship between fungal growth in blood culture and level of 1,3Beta D Glucan.
In the present study the cutoff point for beta D glucan in diagnosis of IFI was 79pg/ml with sensitivity of 71.4% and specificity of 98%.
Results revealed that by day 10 of admission (26.7%) of patients developed clinical signs very likely to have sepsis by tollner score, 26.7% was suspicious and 46.7% was unlikely to have sepsis.
There is a highly significant relationship between positive fungal culture and hepatosplenomegaly as hepatosplenomegaly was noted in 100% of positive fungal culture neonates.
There is non-significant statistical difference between positive fungal culture neonates and negative fungal culture neonates regarding CVC insertion, however 1,3Beta D Glucan levels were higher in those who inserted CVC.
Also, there is a strong positive correlation between Beta D glucan level and sepsis score Tollner, Rodwell and SNAPII as beta D glucan is higher in patients with high sepsis score.
Moreover, neonates with positive fungal culture have statistically significant lower levels of PLT count and higher CRP levels in comparison with negative fungal culture group.