الفهرس 
DIABETES MELLITUSOnly 14 pages are availabe for public view
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Abstract
These antioxidants and oxidants that were spectrometrically measured were: Total antioxidant capacity (TAC), Reduced glutathione, Malondialdehyde level (MDA), Catalase enzyme, Superoxide dismutase, Glutathione peroxidase(GPx), Glutathione reductase, Glutathione S Transferase (GST).
Our study showed that there was significant decrease in glutathione reductase, reduced glutathione, and glutathione peroxidase in the diabetic patients compared to the controls. These changes were steady over the study period as on day 3 of the DKA occurence compared to day 1, and day 5 compared to days 1 and 3. These findings could be explained by the extensive oxidative stress caused by the diabetic ketoacidosis and the consumption of the enzymes. In addition, there is sluggish production of the NADPH by the pentose phosphate pathway.
Also our study showed that there was significant decrease in total antioxidant capacity and catalase, and superoxide dismutase in the diabetic patients compared to the controls. These changes were steady over the study period as on day 3 of the DKA occurrence compared to day 1, and day 5 compared to days 1 and 3. That could be partly explained by excessive production of ROS and that this decreased level was a defense mechanism in response to increased oxidative stress associated with DKA.
Also, we found that there was significant increase in MDA level in diabetic patients compared to controls.
In conclusion, our results confirm the presence of metabolic oxidative stress during DKA on day 1 through day 5 as evidenced by significantly increasing levels of Glutathione peroxidase, malondialdehyde, and Glutathione S transferase.