الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
MicroRNAs (miRNAs) are a large family of small (≈ 22 base) regulatory non-coding RNAs that can bind to 3’ untranslated region (UTR) of target sequence producing either inhibitory (mostly) or enhancing effect that regulating transcriptional levels of the genes. miRNAs have emerged to play important roles in many physiological and pathophysiological processes such as embryonic development, organogenesis, tumor genesis and other human diseases such as arrhythmia, ischemic heart disease, cardiac hypertrophy, viral hepatitis and diabetes. It has been also reported that miRNAs can increase expression of the target genes.
The present work was designed to highlight the role of miRNAs and their adaptor proteins in regulating the mechanisms of some metabolic disorders as obesity and diabetes at the molecular levels on biochemical parameters, enzymes involved in carbohydrates metabolism and histopathological changes.
Type 2 diabetes and obesity induced by feeding rats on high-fat high fructose/sucrose diet (HFHF/S) The rats from (HFHF/S) were given a diet consisting of lard (60%), fructose (17%) added to the standard rat chow and sucrose 10% add to water, the experiment prolonged for 12 weeks.